Blood Cells and Transfusion

Blood is one of the main parts of our body. We can't live without blood. Do you know why? of course because blood plays the main role of controlling our body regulations. This is my note that I got from my tutorial class about blood and transfusion. enjoy! :B
Whole blood:

• red cell concentrate
• platelet concentrate
• fresh frozen plasma
• cryoprecipitate
• white cells (buffy coat)

blood products:

• human albumin solution (5%, 20%)
• coagulation factor concentrate
• immunoglobulin (specific or standard human)

Ab (Antibody) to other red cell antigens appear only after sensitization.

Ab may cause:

• intravascular (e.g. ABO incompatibility) haemolysis of donor red cells in the recipient
• haemolysis disease of the fetus and newborn because of transplacental passage

Red cell transfusion:

• haemorrhage, severe anemia refractory to other therapy or needing rapid correction
• if repeated transfusions likely, phenotyped ABO and Rh compatible red cells which correspond as closely as possible to the minor red cell antigens of the recipient are used to minimize sensitization

Complications of transfusion:

• administrative and clerical errors
• congestive heart failure (caused by circulating overload)
• immunological reaction (may occur with transfusion of cellular and plasma derived blood components. ABO incompatible red cell transfusions may lead to life-threatening intravascular haemolysis of transfused cells with fever, rigors, haemoglobinuria, hypotension, and renal failure. Hypersensitivity reactions to plasma components may cause urticaria, wheezing, facial edema, and pyrexia but can cause anaphylactic shock, especially in IgA-deficient subjects.

that's all. :D I know it's not enough. So, we'll discuss it another time. :)

CHEERS!! :B